By combining SEC with a multi-mode (MM) resin, Apex MM columns significantly enhance EV purity by removing more lipoproteins than SEC alone. By providing superior EV purity, maintaining optimal yield without introducing size biases, and preserving EV functionality, Apex MM columns significantly enhance biomarker discovery and therapeutic research applications.
Optimized for maximum EV purity in plasma/serum samples—optimal for unbiased assays like mass spec and flow cytometry.
| Column Type | Yield | Purity (HSA) | Purity (ApoA1) | Purity (ApoB-100) | Pore-Size |
| Apex MM | 1.5 | 2.2 | 1.1 | 1.8 | <50 nm |
| Competitor | 1.0 | 1.0 | 1.0 | 1.0 | 70 nm |
Everest Biolabs Atlas EV and human serum albumin (HSA) ELISA kits can be used to optimize EV yield and purity during fraction collection.
| Column volume | 9.0 mL |
| Input sample volume | 0.5 - 1.0 mL |
| Sample types | plasma, serum, urine, CSF, cell culture media |
| Resin types | cross-linked agarose plus multi-mode |
| Column reproducibility (CV) | 5% |
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